张江虹

发布者:王晓夏发布时间:2022-09-30浏览次数:168



个人简历

张江虹,医学博士,副研究员,硕士研究生导师。主要从事肿瘤微环境介导辐射抵抗机制的研究,先后在英国牛津大学、英国贝尔法斯特女王大学作访问学者,主持国家自然科学基金、教育部、上海市科委等多项课题,发表本领域高水平论文多篇。


主持科研项目

  1. 张江虹乏氧肺癌细胞外泌体蛋白ANGPTL4通过免疫调节辐射敏感性的机制研究国家自然科学基金面上项目(2022-202512175044),直接经费61万。

  2. 张江虹乏氧诱导的外泌体在肿瘤侵袭转移、血管生成和辐射抵抗中的作用及其机制研究国家自然科学基金面上项目(2017-202081672985),直接经费53万。

  3. 张江虹硫化氢在肝癌细胞乏氧辐射耐受中的作用机制研究国家自然科学基金青年项目(2013-201531200631),23万。

  4. 张江虹硫化氢在乏氧肝癌细胞辐射耐受中的作用和机制研究上海市自然基金2010-201209ZR1403600),10万。

  5. 张江虹气体信号分子硫化氢在乏氧肝癌细胞辐射耐受中的作用和机制研究国家教育部高校博士点基金2010-201220090071120096),3.6万。

  6. 张江虹硫化氢在乏氧引起的肿瘤细胞辐射耐受中的作用和机制研究复旦大学青年科学基金2008-201008FQ25),4万。


发表期刊论文

  1. Yuhong Zhang, Xinglong Liu, Liang Zeng, Xinrui Zhao, Qianping Chen, Yan Pan, Yang Bai, Chunlin Shao*, Jianghong Zhang*. Exosomal protein angiopoietin-like 4 mediated radioresistance of lung cancer by inhibiting ferroptosis under hypoxic microenvironment. British J. Cancer. DOI: 10.1038/s41416-022-01956-7, 2022.

  2. Qianping Chen#, Wang Zheng#, Jian Guan#, Hongxia Liu, Yao Dan, Lin Zhu, Yimeng Song, Yuchuan Zhou1, Xinrui Zhao, Yuhong Zhang, Yang Bai1, Yan Pan1*, Jianghong Zhang*, Chunlin Shao*. SOCS2-enhanced ubiquitination of SLC7A11 promotes ferroptosis and radiosensitization in hepatocellular carcinoma. Cell Death and Differentiation.https://doi.org/10.1038/s41418-022-01051-7.

  3. Wang Zheng†, Qianping Chen†, Hongxia Liu, Liang Zeng, Yuchuan Zhou, Xinglong Liu, Yang Bai, Jianghong Zhang*, Yan Pan*, Chunlin Shao*. SDC1-dependent TGM2 determines radiosensitivity in glioblastoma by coordinating EPG5-mediated fusion of autophagosomes with lysosomes. Autophagy, doi: 10.1080/15548627.2022.2105562, 2022. (IF 13.4)

  4. Xinrui Zhao#, Songling Hu#, Liang Zeng, Xinglong Liu, Yimeng Song, Yuhong Zhang, Qianping Chen, Yang Bai, Jianghong Zhang, Haowen Zhang*, Yan Pan1*, Chunlin Shao*. Irradiation combined with PD-L1-/- and autophagy inhibition enhances the antitumor effect of lung cancer via cGAS-STING-mediated Tcell activation. iScience, 25, 104690, 2022. (IF 5.5).

  5. Yuchuan Zhou, Hongxia Liu, Wang Zheng, Qianping Chen, Songling Hu, Yan Pan, Yang Bai, Jianghong Zhang* and Chunlin Shao*. MMP14 contributes to HDAC inhibition-induced radiosensitization of glioblastoma. Int. J. Mol. Sci., 22(19): 10403, 2021.

  6. Yimeng Song#, Songling Hu#, Junling Zhang, Lin Zhu, Xinrui Zhao, Qianping Chen, Jianghong Zhang, Yang Bai, Yan Pan*, Chunlin Shao*. Fractionated irradiation of right thorax induces abscopal damage on bone marrow cells via TNF-α and SAA. Int. J. Mol. Sci., 22(18): 9964, 2021.

  7. Qianping Chen#, Wang Zheng#, Lin Zhu, Hongxia Liu, Yimeng Song, Songling Hu, Yang Bai, Yan Pan, Jianghong Zhang*, Jian Guan*, Chunlin Shao*. LACTB2 Renders Radioresistance by Activating PINK1/Parkin-dependent Mitophagy in Nasopharyngeal Carcinoma Cells. Cancer Letters. 518: 127–139, 2021.

  8. Wang Zheng#, Qianping Chen#, Hongxia Liu, Songling Hu, Yuchuan Zhou, Yang Bai, Jianghong Zhang, Yan Pan and Chunlin Shao*. CD81 enhances radioresistance of glioblastoma by promoting nuclear translocation of Rad51. Cancers, 13:1998, 2021.

  9. Jianghong Zhang, Yuhong Zhang, Fang Mo, Gaurang Patel, Karl T Butterworth, Chunlin Shao*, Kevin Prise*. The roles of HIF-1α in radiosensitivity and radiation induced bystander effects under hypoxia. Frontiers in Cell and Developmental Biology, 9: 637454, 2020. DOI: 10.3389/fcell.2021.637454, 2021.

  10. Songling Hu#, Lin Zhu#, Yimeng Song#, Xinrui Zhao, Qianping Chen, Yan Pan, Jianghong Zhang, Yang Bai, Haowen Zhang*, Chunlin Shao*.Radiation-induced abscopal reproductive effect is driven by Rac1 nuclear translocation in Sertoli cells. Theranostics. 11(12): 5742-5758, 2021.

  11. Hongxia Liu, Wang Zheng, Qianping Chen, Yuchuan Zhou, Yan Pan, Jianghong Zhang, Yang Bai and Chunlin Shao*. LncRNA CASC19 Contributes to Radioresistance of Nasopharyngeal Carcinoma by Promoting Autophagy via AMPK-mTOR Pathway. Int. J. Mol. Sci. 22(3), 1407, 2021.

  12. Xiaofei Chu, Wang Zheng, Juan Wang, Jianghong Zhang, Yan Pan and Chunlin Shao. CDK6 inhibition targeted by miR-378a-3p protects against intestinal injury induced by ionizing radiation. Biochemical and Biophysical Research Communications. 531: 328-334, 2020.

  13. Fei Chen#, Yushuo Zhang#, Songling Hu, Xiaolin Shi, Zhongmin Wang, Zicheng Deng, Jianghong Zhang, Yan Pan, Yang Bai, Fenju Liu, Haowen Zhang*, Chunlin Shao1*. TIGAR/AP-1 axis accelerates the division of Lgr5 reserve intestinal stem cells to reestablish intestinal architecture after lethal radiation. Cell Death & Disease. 11: 501, 2020..

  14. Chen Wang, Jinping Xu, Dexiao Yuan, Yang Bai, Yan Pan, Jianghong Zhang, Chunlin Shao*. Exosomes from irradiated lung cancer cells carrying ALDOA and ALDH3A1 enhance migration and invasion of recipients by accelerating glycolysis. Molecular and Cellular Biochemistry, 469:77–87, 2020.

  15. Fang Mo, Yanwu Xu, Junling Zhang, Lin Zhu, Chen Wang, Xiaofei Chu, Yan Pan, Yang Bai, Chunlin Shao*, Jianghong Zhang*. Effects of hypoxia and radiation-induced exosomes on migration of lung cancer cells and angiogenesis of umbilical vein endothelial cells. Radiat. Res., 194: 71–80, 2020.

  16. Wang Zheng#, Qianping Chen#, Chen Wang, Xiaofei Chu, Dan Yao, Lin Zhu, Yan Pan, Jianghong Zhang, Yang Bai, Chunlin Shao*. Inhibition of Cathepsin D (CTSD) enhances radiosensitivity in glioblastoma cells through attenuated autophagy. Molecular Carcinogenesis, 59:651–660. 2020.

  17. Qianping Chen#, Wang Zheng#, Lin Zhu, Dan Yao, JunLing Zhang ,Chen Wang, Fang Mo,Yimeng Song, Hongxia Liu, Songling Hu, Xiaofei Chu, Yang Bai, Yan Pan, Jianghong Zhang, Chunlin Shao*. ANXA6 contributes to radioresistance by regulating cell autophagy and migration in nasopharyngeal carcinoma. Frontiers in Cell and Developmental Biology, 8:232, 2020.

  18. Fei Guo, Dexiao Yuan, Junling Zhang, Hang Zhang, Chen Wang, Lin Zhu, Jianghong Zhang, Yan Pan* and Chunlin Shao*. Silencing of ARL14 Gene Induces Lung Adenocarcinoma Cells to a Dormant State. Frontiers in Cell and Developmental Biology, 2019 Oct 15; 7: 238. doi: 10.3389/fcell.2019.00238. eCollection 2019.

  19. Junling Zhang#, Dan Yao#, Yimeng Song, Yan Pan, Lin Zhu, Yang Bai, Yanwu Xu, Jianghong Zhang*, Chunlin Shao*. Fractionated irradiation of right thorax induces abscopal damage on testes leading to decline in fertility. Scientific Reports, 9:15221, 2019.

  20. Junling Zhang#, Dan Yao#, Jianghong Zhang, Yimeng Song, Fang Mo, Xiaofei Chu, Yan Pan, Yang Bai, Chunlin Shao*. TGF-β mediates thoracic radiation-induced abscopal effects of testis injury in rat. Biochemical and Biophysical Research Communications. 514(3): 678-683, 2019.

  21. Xiangdong Wang, Wenzhi Tu, Chen Dong, Jiamei Fu, Juan Wang, Chunlin Shao*, Jianghong Zhang*. Autophagy suppresses radiation damage by activating PARP-1 and attenuating reactive oxygen species in hepatoma cells.Int. J. Radiat. Biol.95(8): 1051-1057, 2019.

  22. Chen Wang, Wang Zheng, Dan Yao, Qianping Chen, Lin Zhu, Junling Zhang, Yan Pan, Jianghong Zhang, Chunlin Shao*. Upregulation of DNA metabolism-related genes contributes to radioresistance of glioblastoma. Human Gene Therapy Clinical Development. 30(2): 74-87, 2019.

  23. Chen X, Wang P, Guo F, Wang X, Wang J, Xu J, Yuan D, Zhang J*, Shao C*. Autophagy enhanced the radioresistance of non-small cell lung cancer by regulating ROS level under hypoxia condition. Int. J. Radiat. Biol. 93(8): 764-770, 2017.

  24. Yuexia Xie, Shuang Ye, Jianghong Zhang, Mingyuan He, Chen Dong, Wenzhi Tu, Peifeng Liu, Chunlin Shao*. Protective effect of mild endoplasmic reticulum stress on radiation-induced bystander effects in hepatocyte cells.Scientific Reports,6:38832, 2016.

  25. Yuan D, Xu J, Wang J, Pan Y, Fu J, Bai Y, Zhang J*, Shao C*. Extracellular miR-1246 promotes lung cancer cell proliferation and enhances radioresistance by directly targeting DR5. Oncotarget. 7(22): 32707-22, 2016.

  26. Pan, Y., Zhou, C., Yuan, D., Zhang, J. and Shao C*. Radiation Promotes Hepatocarcinoma Cell Invasiveness through Epithelial Mesenchymal Transition Mediated by H2S/CSE Pathway. Radiat. Res. 185: 96–105, 2016.

  27. Xiangdong Wang, Jianghong Zhang*, Jiamei Fu, Juan Wang, Shuang Ye, Weili Liu, Chunlin Shao*. Role of ROS-mediated autophagy in radiation-induced bystander effect of hepatoma cells. Int. J. Radiat. Biol., 91(5): 452–458, 2015.

  28. Yuexia Xie#, Wenzhi Tu#, Jianghong Zhang, Mingyuan He, Shuang Ye, Chen Dong, Chunlin Shao*. SirT1 knockdown potentiates radiation-induced bystander effect through promotion of c-Myc activity that facilitates ROS accumulation. Mutation Research--Fundamental and Molecular Mechanisms of Mutagenesis.772: 23-29, 2015.

  29. Yan Pan, Shuang Ye, Dexiao Yuan, Jianghong Zhang, Yang Bai, Chunlin Shao*. Hydrogen sulfide (H2S)/cystathionine γ-lyase (CSE) pathway contributes to the malignant proliferation of hepatoma cells.  Mutat. Res. --Fundamental and Molecular Mechanisms of Mutagenesis. 763–764: 10–18, 2014.

  30. Yan Pan, Shuang Ye, Dexiao Yuan, Jianghong Zhang, Yang Bai, Chunlin Shao*.Radioprotective role of H2S/CSE pathway in Chang liver cellsMutat. Res. --Fundamental and Molecular Mechanisms of Mutagenesis. 738-739: 12-18, 2012.

  31. Zhang J, Xie Y, Xu Y, Shao C*. Suppression of Endogenous Hydrogen Sulfide Contributes to the Radiation-Induced Bystander Effects on Hypoxic HepG2 Cells.Radiat. Res. 178: 395–402, 2012.

  32. Yuexia Xie, Jianghong Zhang, Mingyuan He, Ruiping Ren, Shuang Ye, Dexiao Yuan, Chunlin Shao*. SirT1 regulates radiosensitivity of hepatoma cells differently under normoxia and hypoxia conditionsCancer Sci. 103(7): 1238-1244.

  33. Yuexia Xie, Jianghong Zhang, Yanwu Xu, Chunlin Shao. SirT1 confers hypoxia-induced radioprotection via the modulation of c-Myc stabilization on hepatoma cellsJ. Radiat. Res., 53(1): 44-50, 2012.

  34. 张育红,邵春林,张江虹,血管生成素样蛋白在肿瘤发生发展中的作用,国际放射医学核医学杂志,43(5): 403-4082021

  35. 白杨,张俊玲,姚丹,张江虹,邵春林,西咪替丁对胸部分割照射小鼠脾脏损伤的治疗作用, 中华放射医学与防护杂志,40(3): 178-1822020

  36. 陈晓艳,张江虹,邵春林,STAT3与辐射敏感相关性的研究进展,国外放射医学与核医学杂志,40(3): 191-1952016

  37. 肖林林,金问森,张江虹,邵春林,电离辐射诱发动脉粥样硬化的研究进展,国际放射医学核医学杂志,39(6): 493-496, 2015

  38. 徐金苹,袁德晓,张江虹,邵春林,辐射诱导的外泌体在肿瘤细胞侵袭转移中的作用,国际放射医学核医学杂志,39(2): 144-148, 2015

  39. 王向东,张江虹,邵春林,自噬与乏氧肿瘤细胞辐射抵抗,中华放射医学与防护杂志,34(2)155-1582014


授权发明专利:

  1. 邵春林,袁德晓,潘燕,叶爽,张江虹,白杨,一种检测电离辐射剂量的生物学方法,申请号:201110333811.X,申请日期2011-10-28,申请公布号:CN 102508283 A,公布日:2012-6-20. 批准号:第1202428号,2013-5-29

  2. 邵春林,郭飞,潘燕,张江虹,朱琳,张俊伶,ARL14作为肿瘤标志物在制备预测肺癌预后及靶点药物中的用途,申请号:201810780843.6,申请日期:2018717日。申请公布号: CN 110714076 A,申请公布日:2020-1-21。专利授权发文序号:2022081800587050。


联系方式

上海市斜土路2094号,邮编200032;电话:021-64436075,邮箱:zjh551268@fudan.edu.cn